The Relationship Between Ultraviolet B and DNA Methylation in Skin Cancers
Ultraviolet B is regarded as an important factor in many skin diseases, especially skin cancers. Increasingly more evidence is showing that changes in DNA methylation occur in patients with skin cancers. Changes in DNA methylation have also been observed in ultraviolet B-irradiated cells and mouse models. DNA methylation modifier enzymes are simultaneously affected. We herein review the evidence to date showing that Ultraviolet B affects changes in DNA methylation modifier enzymes in skin cancers. However, the mechanism of how ultraviolet B regulates the changes in DNA methylation modifier enzymes remains to be further elucidated. Understanding the mechanism by which ultraviolet B modulates DNA methylation modifier enzymes can help to identify potential therapeutic markers or targets and develop novel strategies for preventing or treating ultraviolet B-induced skin damage.
DNA methylation、DNA methyltransferases、skin cancers、ten-eleven translocations、ultraviolet B
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Natural Science Foundation of Jiangsu ProvinceNo. BK20191136;Fundamental Research Funds for the Central UniversitiesNo. 3332019104;Open Project of Jiangsu Biobank of Clinical ResourcesNo. JSSWYB2020-05-003
2024-01-30（万方平台首次上网日期，不代表论文的发表时间）
共6页
157-162
