Efficacy of Acitretin Monotherapy on Basal Cell Carcinoma: A Case Report
Introduction::Basal cell carcinoma (BCC) is the most common skin cancer which mainly affects the population over 50 years of age. In addition to surgical treatment, nonsurgical treatment is also an attractive option for some patients.Case presentation::An 82-year-old man presented with BCC on his left nose wing more than 2 years ago. Due to his unwillingness to accept treatment that may lead to pain, discomfort, or trauma, the patient was prescribed oral acitretin 25 mg twice daily [0.8 mg/(kg·d)] and was instructed to apply 2% fusidic acid cream topically once daily for trauma protection. The lesion progressively shrank in size after 4 weeks of treatment, and was almost completely resolved after 28 weeks of follow-up. The patient reported mild adverse effects, such as mild skin fragility and cheilitis, and apparent scaling skin, which caused minor discomfort but did not affect the continuation of treatment.Discussion::The pathogenesis of BCC is still unclear, but it has been demonstrated to be linked to overactive hedgehog signaling and its crosstalk with other pathways such as phosphoinositide 3-kinase and mammalian target of rapamycin. Acitretin could obviously inhibit cell growth and proliferation and down-regulate AMP-dependent protein kinases that plays critical role in the blocking of malignant progression of several tumors including BCC.Conclusion::We provide an effective alternative for the patients with BCC who are unwilling to receive surgical therapy.
acitretin、monotherapy、basal cell carcinoma
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Natural Science Foundation of GuangdongNo. 2020A1515010275;Characteristic Clinic Project of Guangzhou Health CommissionNo. 2019TS68;Medical and Health Technology Projects of GuangzhouNo. 20191A010052
2023-05-30（万方平台首次上网日期，不代表论文的发表时间）
共3页
172-174
