Skin Organoid Research Progress and Potential Applications
Skin diseases were characterized by various types and high incidence, which seriously affect people’s health. At present, skin pathogenesis research and the therapeutic drug development for skin diseases are limited by the lack of reasonable research models that recapitulate the development of skin diseases. Organoids are three-dimensionally cultured cell populations derived from skin stem cells, which exhibits the ability of multicell assembly and the similar histological characteristics with the living tissues and organs. This article reviews the establishment of normal skin organoids and skin tumor organoids, and summarizes the application of skin organoids in the evaluation of drug sensitivity, pathological mechanism research, and individualized treatment. In addition, the advantages and limitations of organoids in skin disease research are also discussed, which provides a basis for revealing the pathogenesis of skin diseases and developing preventive and therapeutic drugs for skin diseases.
skin disease、organoid、three-dimensional culture、personalized treatment、drug screening
05
2023-05-30（万方平台首次上网日期，不代表论文的发表时间）
共6页
101-106
