Aberrant DNA Methylation in Cutaneous Squamous Cell Carcinoma

摘要：

IntroductionCutaneous squamous cell carcinoma (CSCC) is the secondmost common non-melanoma skin cancer after basal cell carcinoma, accounting for 20％ of all cutaneous malignancies. CSCC originates from epidermal keratinocytes or adnexal structures such as eccrine glands or pilosebaceous units.1 According to several studies focused on Caucasian populations in Europe, the USA and Australia, about 15– 35 per 100,000 individuals are diagnosed with CSCC each year, and the incidence of CSCC is expected to increase by 2％–4％ per year.2 The incidence of primary CSCC has increased by 50％–300％ globally, especially amongst Caucasian populations in New Zealand, Australia, and North America over the last 3 decades.

机标关键词：Squamous Cell Carcinoma、squamous cell carcinoma、basal cell carcinoma、North America、New Zealand

所属期刊栏目：2

分类号：R73;R78

资助基金：Our work was supported by grants from the Chinese Academy Medical Sciences Initiative for Innovative Medicine2016-I2M-3-021;National Natural Science Foundation of China31470274;Jiangsu Key Laboratory of Molecular Biology for Skin Diseases and STIs2012ZD006;Jiangsu provincial SixTalent Peaks2013-WSW-060

在线出版日期：2020-01-11（万方平台首次上网日期，不代表论文的发表时间）

页数：共6页

页码：227-232