Zebrafish Model of Hereditary Pigmentary Disorders
IntroductionPigmentary disorders are a heterogeneous group of hereditary or acquired disorders characterized by varying degrees of hyperpigmentation and/or hypopigmentation. Pigmentary disorders originate from abnormalities in melanocyte development, defects in melanin synthesis, or changes in melanosome transfer.1-2 Several skin pigmentation disorders and diseases are heritable, including dyschromatosis universalis hereditaria (DUH), Dowling- Degos disease (DDD), and albinism. To elucidate the pathogenesis of these heritable pigmentary disorders, a cross-species approach has been widely applied and has resulted in a detailed understanding of melanocyte physiology and pathophysiology.
pigmentation disorders
2
R2
2020-01-11(万方平台首次上网日期,不代表论文的发表时间)
共5页
216-220