Calcineurin/Nuclear Factor of Activated T-Cell Pathway in Cutaneous Squamous Cell Carcinoma
IntroductionCutaneous squamous cell carcinoma (CSCC),a keratinocyte-derived skin neoplasm with malignant potential,1 represents 20％-50％ of skin cancers and currently has an increasing incidence in the United States.2 Ultraviolet (UV)solar radiation is the primary risk factor for the development of CSCC,and the cumulative exposure received over a lifetime plays a major role in this development.3 Mutations in the p53 gene are the most common genetic abnormalities,causing nonfunctional p53 protein production and cells with damaged DNA replicate in CSCC.4
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Our work was supported by Grants from the Chinese Academy Medical Sciences Initiative for Innovative Medicine2016-I2M-3-021;National Natural Science Foundation of China31470274;Jiangsu Key Laboratory of Molecular Biology for Skin Diseases and STIs2012ZD006;Jiangsu provincial SixTalent Peaks2013-WSW-060
2019-10-31（万方平台首次上网日期，不代表论文的发表时间）
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156-159
