Advances in postoperative radiotherapy for keloids

摘要：

IntroductionKeloids, a type of skin lesion that presents as patho-logically excessive dermal fibrosis and aberrant wound healing, are caused by cell proliferation and hyaline degeneration of connective tissues. The specific pathogenesis of keloids is still unknown”1-2”. There are multiple therapeutic strategies for keloids, including surgery, cryotherapy, laser or light-based therapy, and intralesional corticosteroid injection. However, none of these is optimal. Surgical excision combined with adjuvant radiation is considered to be a safer and more efficacious method”3”. From publicly available data, the recurrence rate of keloids after simple surgical excision amounts to 45％-100％”4”. Based on published reports, postoperative radiotherapy results in a control rate of 67％- 81％, and the recurrence rate decreases to 24.5％-35％”4-12”. This article reviews papers related to postoperative radiotherapy treatment for keloids, and also discusses radiation types, parameters, safety and effectiveness.

所属期刊栏目：1

资助基金：the National Natural Science Foundation of China81872545 and 81703152;the CAMS Innovation Fund for Medical SciencesCIFMS-2017-I2M-1-017

在线出版日期：2019-01-09（万方平台首次上网日期，不代表论文的发表时间）

页数：共5页

页码：212-216