National Key R&D Program of China2016YFE0126000;National Natural Science Foundation of China81570392;Project of Jiangsu Provincial Health and Family Planning Commission of ChinaQNRC2016353;Key Project of Innovative Training Program for College Students in Jiangsu Province,China 201811117005Z国家重点研发项目2016YFE0126000;国家自然科学基金81570392;江苏省卫计委项目QNRC2016353;江苏省高等学校大学生创新训练计划重点项目201811117005Z