国家自然科学基金青年科学基金81600643;天津市自然科学基金17JCYBJC27000;天津市卫生健康科技项目ZC20128;天津市卫生健康科技项目RC20175;天津市研究生科研创新项目2019YJSS187;National Science Foundation for Young Scientists of China81600643;Tianjin Natural Science Foundation of China17JCYBJC27000;Tianjin Health Science and Technology ProjectZC20128;Tianjin Health Science and Technology ProjectRC20175;Tianjin Research Innovation Project for Postgraduate Students2019YJSS187