国家自然科学基金81372928、81573094;中国医学科学院医学与健康科技创新工程项目2017-I2M-3-015;国家重点研发计划2017YFA0105200National Natural Science Foundation of China81372928,81573094;CAMS Innovation Fund for Medical Sciences2017-I2M-3-015;National Key Research and Development Program of China2017YFA0105200