Crystal Structures of Arabidopsis thaliana Nudix Hydrolase NUDT7 Reveal a Previously Unobserved Conformation
Dear Editor,Nudix hydrolases are a superfamily of phylogenetically widespread enzymes that catalyze the hydrolysis of nucleoside diphosphate linked to another moiety X (NDP-X) to yield nucleoside monophosphate and P-X.Within the superfamily,at least four families are classified based on their substrate specificities:the MutT family hydrolases,the ADPR pyrophosphatases,the NADH hydrolases,and the adenosine-(p)n-adenosine hydrolases (Bessman et al.,1996;Gabelli et al.,2001).Arabidopsis thaliana contains 27 Nudix enzymes whose biological functions are not well understood except for NUDT7 (Ogawa et al.,2005).
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This work was supported by grants from the National Natural Science Foundation of China 31170690 and the Ministry of Science and Technology of China 2011CB911102.
2016-01-16（万方平台首次上网日期，不代表论文的发表时间）
1557-1559
