P-Loop-Dependent NLR SNC1 Can Oligomerize and Activate Immunity in the Nucleus
Dear Editor,Upon recognition of pathogen effectors,plant resistance (R) proteins trigger strong defense responses that restrict the growth and spread of pathogens.Most R proteins are nucleotide-binding (NB) and leucine-rich repeat (LRR) domain-containing proteins (NLRs) sharing structural similarity with animal NOD-like receptors (Dodds and Rathjen,2010).SNC1 (Suppressor of npr1,constitutive 1) is an Arabidopsis Toll/interleukin-1 Receptor (TIR)-type NLR that was originally identified through a gain-of-function autoimmune mutant,snc1,from a forward genetic screen.
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This research is supported by grants from the Natural Sciences and Engineering Research Council of Canada NSERC Discovery program and the Dewar Cooper Memorial Fund from the University of British Columbia.No conflict of interest declared.
2015-02-02(万方平台首次上网日期,不代表论文的发表时间)
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