Genome-wide identification of imprinted genes in pigs and their different imprinting status compared with other mammals

摘要：

DEAR EDITOR,
Genomic imprinting often results in parent-of-origin specific differential expression of maternally and paternally inherited alleles and plays an essential role in mammalian development and growth.Mammalian genomic imprinting has primarily been studied in mice and humans,with only limited information available for pigs.To systematically characterize this phenomenon and evaluate imprinting status between different species,we investigated imprinted genes on a genome-wide scale in pig brain tissues.Specifically,we performed bioinformatics analysis of high-throughput sequencing results from parental genomes and offspring transcriptomes of hybrid crosses between Duroc and Diannan small-ear pigs.We identified 11 paternally and five maternally expressed imprinted genes in pigs with highly stringent selection criteria.Additionally,we found that the KCNQ1 and IGF2R genes,which are related to development,displayed a different imprinting status in pigs compared with that in mice and humans.This comprehensive research should help improve our knowledge on genomic imprinting in pigs and highlight the potential use of imprinted genes in the pig breeding field.

所属期刊栏目：41

资助基金：This work was supported by the Ministry of Agriculture of China;National Key R&D Program of China;and Science & Technology Department of Yunnan Province;Animal Branch of the Germplasm Bank of Wild Species,Chinese Academy of SciencesLarge Research Infrastructure Funding

在线出版日期：2021-02-02（万方平台首次上网日期，不代表论文的发表时间）

页数：共5页

页码：721-725