10.24272/j.issn.2095-8137.2018.069
Current understanding on the roles of gut microbiota in fish disease and immunity
Intensive aquaculture has increased the severity and frequency of fish diseases.Given the functional importance of gut microbiota in various facets of host physiology,modulation of this microbiota is a feasible strategy to mitigate emerging diseases in aquaculture.To achieve this,a fundamental understanding of the interplay among fish health,microbiota,and invading pathogens is required.This commentary focuses on current knowledge regarding the associations between fish diseases,dysbiosis of gut microbiota,and immune responses.Furthermore,updated research on fish disease from an ecological perspective is discussed,including colonization resistance imposed by commensals and strategies used by pathogens to overcome resistance.We also propose several directions for future research,such as exploration of the causal links between fish diseases and specific taxa,and identification of universal gut microbial biomarkers for rapid disease diagnosis.
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the Program for the National Natural Science Foundation of China31772876,31372555;Natural Science Foundation of Zhejiang ProvinceLZ18C190001;Natural Science Foundation of Ningbo City of China2017A610284;Scientific Innovation Team Project of Ningbo2015C110018;K.C.Wong Magna Fund in Ningbo University
2019-05-09（万方平台首次上网日期，不代表论文的发表时间）
共7页
70-76
