Absence of mutation in miR-34a gene in a Chinese longevity population
DEAR EDITOR:Centenarians are a typical longevity model characterized by delayed onset of morbidity in age-related diseases such as cancer,cardiovascular disease,dementia,and stroke (Andersen et al,2012).Though there may be a number of underlying mechanisms behind this longevity,curiously it seems that the survival advantage persists in their offspring (Terry et al,2003),suggesting a potentially important role for genetic factors.Previous studies suggested that the heritability of human longevity may be ～25％ (Herskind et al,1996;Mcgue et al,1993),whicih is consistent with other studies on model organisms that identified several longevity-related genes,such as age-1,daf-2,daf-16,and sir-2 (Friedman & Johnson,1988;Kenyon et al,1993;Lin et al,1997;Tissenbaum & Guarente,2001).Likewise,several studies have reported the existence of many mutations related to human longevity (Holstege et al,2014;Sebastiani et al,2012).
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This study was supported by grants from the Yunnan Applied Basic Research Project 2013FB069
2015-04-29（万方平台首次上网日期，不代表论文的发表时间）
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