the General Program of Chongqing Natural Science Foundation of ChinaCSTC2014jcyjA10012;the Project of Science and Technology Plan of Chongqing2014-21;the National Clinical Key-discipline Construction Program of China 2013-544.重庆市自然科学基金面上项目CSTC2014jcyjA10012;重庆市科技计划项目渝科发计[2014]21号;国家临床重点专科建设项目国卫办医函[2013]544号