国家自然科学基金青年科学基金81500208;全军医学科技青年培育项目14QNP050;四川省科技支持计划项目2015JY0277Supported by the National Natural Science Foundation for Young Schloars of China 81500208,the Medical Science and Technological Training Program for Youths of PLA 14QNP050,and the Supporting Project of Science and Technology Plan of Sichuan Province 2015JY0277.