the National Natural Science Foundation of China81001677;the Postdoctoral Science Foundation of China2011M500153;the Natural Science Foundation of Chongqing2010BB5171;the Innovation Foundation for Young Talent of Third Military Medical University2010XQN03;国家自然科学基金81001677;中国博士后科学基金2011M500153;重庆市自然科学基金2010BB5171;第三军医大学青年人才创新基金2010XQN03