Governing glutaminolysis by regulation of glutaminase succinylation

摘要：

Of the 20 ribosomally coded amino acid residues,lysine(K)can be frequently and uniquely modified by many types of posttranslational acylation,including acetylation,suc-cinylation,crotonylation,propionylation,butyrylation,glu-tarylation,malonylation,β-hydroxybutyrylation,and 2-hydroxyisobutyrylation in histones and other proteins(Li et al.,2018a;Xu et al.,2021).Among these acylations,succinylation is a commonly occurred modification,and histone H3K79 succinylation is identified in the transcription start sites of more than 7,000 genes,implying its critical role in the expression regulation of a large number of genes(Wang et al.,2017).

机标关键词：glutaminase、glutaminolysis、governing、regulation、succinylation

所属期刊栏目：13

分类号：S881.2;F270.7

在线出版日期：2022-05-19（万方平台首次上网日期，不代表论文的发表时间）

页数：共4页

页码：163-166