ALKBH1 deficiency leads to loss of homeostasis in human diploid somatic cells

摘要：

Dear Editor,
As the most prevalent DNA methylation modification in prokaryotes, DNA N6-methyladenosine (6mA)in eukaryotic genomes has recently been observed in diverse species including Caenorhabditis elegans (Greer et al., 2015), Drosophila melanogaster (Zhang et al., 2015), mouse (Wu et al.,2016) and human (Xiao et al., 2018).6mA has been reported to associate with multiple physiological processes including embryonic development and tumorigenesis (Greer et al.,2015;Zhang et al., 2015;Xie et al., 2018), yet some controversies exist.

所属期刊栏目：11

资助基金：We are grateful to Lei Bai,Qun Chu,Ruijun Bai,Jing Lu,Ying Yang and Shikun Ma for administrative assistance;Junying Jia IBP,CASand Shuang Sun IBP,CAS for FACS experiments;Zhensheng Xie ;the Strategic Priority Research Program of the Chinese Academy of Sciences ;the National Key Research and Development Program of China ;the National Natural Science Foundation of China ;the Program of the Beijing Municipal Science and Technology Commission ;Beijing Natural Science Foundation ;Beijing Municipal Commission of Health and Family Planning ;Advanced Innovation Center for Human Brain Protection ;the Key Research Program of the Chinese Academy of Sciences ;K.C.Wong Education Foundation ;Young Elite Scientists Sponsorship Program by CAST,Youth Innovation Promotion Association of CAS,the State Key Laboratory of Stem Cell and Reproductive Biology and the State Key Laboratory of Membrane Biology

在线出版日期：2020-11-02（万方平台首次上网日期，不代表论文的发表时间）

页数：共8页

页码：688-695