The expanded development and application of CRISPR system for sensitive nucleotide detection
CRISPR/Cas system, originally developed as genetic editing tool, also shows great potentials for nucleotide detection.A recent study published in Molecular Cell (Freije et al., 2019)developed a Cas13a-based CARVER (Cas13-assisted restriction of viral expression and readout) to detect RNA viruses such as lymphocytic choriomeningitis, influenza A and vesicular stomatitis, which provided a potential expanded application for the detection of a broad range of viral nucleotides in disease diagnosis.
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The work was supported by grants from the National Key Research and Development Program of China ;the National Natural Science Foundation of China ;the Fundamental Research Funds for the Central Universities of Tongji University ;the SAAS Program for Excellent Research Team ;the Shanghai Leading Talent Project ;the Shanghai Fresh Corn Technology System Project
2020-11-02（万方平台首次上网日期，不代表论文的发表时间）
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