LHX6 is essential for the migration of human pluripotent stem cell-derived GABAergic interneurons
Dear Editor,
GABAergic intemeurons (GIs) play an essential inhibitory role in regulating neural circuitry and neurological activities.Approximately 54％ GABAergic interneuron population originated from medial ganglionic eminence (MGE) at E13.5 in rodents (Butt et al.,2005),and migrated from MGE to dorsal cortex tangentially starting at E13-14 after the GABAergic neurons become postmitotic.Dysfunction of GABAergic interneurons causes severe neurological diseases,such as autism,schizophrenia and depression.Recent years,many studies have shown transplantation of GIs improved the neuronal function of animal models such as epilepsy,neuropathic pain,and fear erasure (Bráz et al.,2012;Cunningham et al.;Yang et al.,2016).Since migration is the intrinsic nature of GIs,regulation of GIs migration could be essential for cell therapy.However,the mechanism of human GIs migration remains unknown,which brings difficulties to control cell migration after transplantation.
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We thank Dr;Su-Chun Zhang Waisman Center and WiCell Research Institute at the University of Wisconsin for kindly providing the AAVS1-TALEN plasmids and crispr-cas9 plasmids;This study was supported by the Strategic Priority Research Program of the Chinese Academy of Sciences ;the National Natural Science Foundation of China Grants ;the National Key Research and Development Program of China ;the Jiangsu Outstanding Young Investigator Program ;and the Jiangsu Province's Innovation Program,Postgraduate Research and Practice Innovation Program of Jiangsu Province
2020-06-02（万方平台首次上网日期，不代表论文的发表时间）
共6页
286-291
