DNA-dependent protein kinase catalytic subunit (DNA-PKcs) contributes to incorporation of histone variant H2A.Z into nucleosomes
Dear Editor,Current research has demonstrated that the dynamic distribution of histone variant H2A.Z at specific loci can be regulated by ATP-dependent chromatin remodelers,histone chaperones and histone post-translational modifications (PTMs).ATP-dependent chromatin remodelers such as the yeast Swr1,p400/rip60 and human SRCAP complexes are mainly responsible for the presence of H2A.Z at specific loci by replacement of H2A with H2A.Z (Ruhl et al.,2006).On the other hand,it is widely believed that the H2A.Z substituted into nucleosomes removed by the INO80 chromatin remod-eling complex (Alatwi and Downs,2015).It has also been shown that the INO80 complex plays a role in removing H2A.Z at the p53-binding site of p21 in response to doxorubicin in U2OS osteosarcoma cells (Ding et al.,2018).In addition to the chromatin remodeler,ANP32E is an H2A.Z chaperone that specifically removes H2A.Z from the nucleosomes (Obri et al.,2014).When DNA damage occurs,H2A.Z is transiently retained at double strand breaks (DSBs);this accumulation can be removed by ANP32E via direct interaction with the αC-helix of H2A.Z (Mao et al.,2014).
DNA damage
10
National Natural Science Foundation of China .31371311 and 31771421
2019-12-30（万方平台首次上网日期，不代表论文的发表时间）
共6页
694-699
