Channel activity of mirror-image M2 proton channel of influenza A virus is blocked by achiral or chiral inhibitors
Dear Editor,It is known that most of lives on the earth compose of homochiral molecules of L-amino acids and D-ribose nucleic acids.However,little is known why and how the life”s chirality in such a way.Studies on an artificial mirror-image life could strengthen our understanding of the question about the origin of life on the Earth and even elsewhere in the universe.Especially studies on mirror-image life would also have a plenty of vast application prospects in materials,energy and pharmaceutical sciences (Bohannon,2010).Recently,several significant preliminary explorations on soluble proteins have been conducted.For instance,the Kent”s group achieved the chemical synthesis of enantiomeric HIV-1 protease and found its mirror-image specificity on the peptide substrate (Milton et al.,1992).The d-DapA was synthesized to study chaperone-assisted protein folding problems (Weinstock et al.,2014).The mirror-image ASFV pol X polymerase was synthesized and performed the mirror-image genetic replication and transcription in the central dogma (Wang et al.,2016).A thermostable d-Dpo4 for mirror-image PCR was also successfully achieved (Xu et al.,2017).These pioneering works open a window for studies of mirror-image lives.However,the mirror-image hydrophobic membrane proteins and their functional property studies remain untouched.Similar as hydrophilic proteins,mirrorimage studies of membrane proteins (e.g.,ion channels) will provide more insights about mirror-image cells or lives.
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the National Basic Research Program 973 Program.2015CB910103 and 2016YFA0400903;the National Natural Science Foundation of ChinaGrant .91753120 and U1732161
2019-05-09（万方平台首次上网日期，不代表论文的发表时间）
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