Synaptonemal complex protein 2 (SYCP2) mediates the association of the centromere with the synaptonemal complex
Dear Editor,In nearly all diploid eukaryotes,meiosis is the key phase in sexual reproduction.The typical process is completed by a round of DNA replication followed by two consecutive rounds of chromosome cell division (Ma et al.,2014;Page and Hawley,2004).Homologous chromosome pairing and segregation occur in the first round of meiosis and is unique to mitosis.The second round of meiosis bears a similarity to the separation of sister chromatids.These events are crucial to eukaryotic fertility and are evolutionarily conserved from yeast to humans (Page and Hawley,2004).A new individual phenotype is often different from that of the parents.Variation and diversity are mediated by the synapsis of homologous chromosomes and by genetic recombination.The mechanism of homology search and alignment remain elusive.One hallmark of the first round of meiosis is the assembly and disassembly of the synaptonemal complex (SC) (Ma et al.,2014).Some studies have shown that the SC plays an indispensable role in crossover formation and genetic exchange.If the SC is disrupted,the meiosis process becomes corrupted,leading to infertility,and even termination of the embryo (Kouznetsova et al.,2011).Down syndrome is a clinical example of defective SC formation (Bolor et al.,2009).
sexual reproduction、chromosome pairing、cell division
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S51;P7
the National Basic Research Program 973 Program.2012CB917200 and 2013CB910400 to YS,2014CB910201 to XY;the National Natural Science Foundation of ChinaGrant .31570750 and 31370826 to YS,31300628 to XY;Tianjin Basic Research ProgramGrant 14JCQNJ09300 to XY
2017-08-18（万方平台首次上网日期，不代表论文的发表时间）
共6页
538-543
