Rab1A mediates proinsulin to insulin conversion in β-cells by maintaining Golgi stability through interactions with golgin-84
Dear Editor,Insulin plays a critical role in mammalian glucose homeostasis,and dysfunctional insulin secretion results in diabetes.Insulin maturation in pancreatic β cells can be generally divided into three stages:the first stage is the biosynthesis of proinsulin in the endoplasmic reticulum (ER),the second stage is the transport of proinsulin from the ER into the Golgi,and the third stage is the cleavage of proinsulin into insulin and C peptide in immature insulin granules (Dodson and Steiner,1998).
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This work was supported by grants to Wu JR from the National Natural Science Foundation of China Grant Nos.31130034 and 31470808,and Strategic Priority Research Program of the Chinese Academy of Sciences XDA12000000.
2016-11-08（万方平台首次上网日期，不代表论文的发表时间）
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