Eliminate mitochondrial diseases by gene editing in germ-line cells and embryos
Nuclease-based gene editing technologies have opened up opportunities for correcting human genetic diseases.For the first time,scientists achieved targeted gene editing of mitochondrial DNA in mouse oocytes fused with patient cells.This fascinating progression may encourage the development of novel therapy for human maternally inherent mitochondrial diseases.
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This work was supported by the National High Technology Research and Development Program of China 863 Program 2015AA020307,National Basic Research Program 973 Program No.2014CB910500,National Natural Science Foundation of China Grant Nos.81371342 and 81422017,Beijing Natural Science Foundation 5142016,Key Research Program of the Chinese Academy of Sciences KJZDEW-TZ-L05,the Thousand Young Talents program of China.
2015-12-21（万方平台首次上网日期，不代表论文的发表时间）
472-475
