Structural implications of Dpy30 oligomerization for MLL/SET1 COMPASS H3K4 trimethylation
Dear Editor,The methylation modifications of histone 3 lysine 4 (H3K4) have essential effects on biological processes including gene expression and transcription,cell cycle progression,and DNA repair.From yeast to mammals,the SET1 and MLL-like (mixed-lineage leukemia) multi-subunit protein complexes,known as SET1 or MLL COMPASS (Schneider et al.,2005),are responsible for H3K4 methylation.
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This work was supported by the National Natural Science Foundation of China Grant Nos.30900230 and 31021062 and the National Basic Research Program 973 Program No.2011CBA00902.
2015-05-20（万方平台首次上网日期，不代表论文的发表时间）
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