国家重大专项项目2016ZX05003002-004,2016B-0502;中国科学院先导专项XDB10010103;国家自然科学基金项目41072105[National Science and Technology Major Project,No.2016ZX05003002-004,2016B-0502;CAS Priority Research Program,No.XDB10010103;National Natural Science Foundation of China,No.41072105]