grants from the National Natural Science Foundation of China31370197 and 21572173;the Hubei Province”s Outstanding Medical Academic Leader Program523-276003;the major projects of technological innovation of Hubei Province2016ACA150 and 2016CFA062;the Science and Technology Program of Wuhan 201150530141.国家自然科学基金31370197;题目:以丙型肝炎病毒RNA-G4为新型靶标的配体分子的筛选及其抗病毒火星的研究;国家自然科学基金21572173;题目:基于适配子靶向病毒蛋白的策略研究HCV导致肝癌的机制与规律