53. Studies for Effects on Fertility and Early Embryonic Development to Implantation of Qingling-Sibutramine hydrochloride in Mice
To better understand the safety property to reproductive and development in human of Qingling-Sibutramine hydrochloride (Ql-Sibutramine), a study of toxic effects/disturbances resulting from treatment from before mating (males/females) through mating and implantation of Ql-Sibutramine in mice were conduc-ted. Ql-Sibutramine was administrated in drink water. A premating treatment interval of 8 weeks for male and 2 weeks for female were done in mice. Treatment was continued throughout mating to termination of males and through implantation for female. The dosages were 32 mg*kg-1*d-1 (1/5 LD50), 2.83 mg*kg-1*d-1, 0.25 mg*kg-1*d-1, and a control group. Assessment of maturation of gametes, mating behavior, fertility, preimplantation stages of the embryo, implantation and toxicity to the parent mice were done. The boby weight lose was observed in the group of 32 mg*kg-1*d-1 in male mice. No other toxic effects in the parent mice and offspring were observed.
Qingling-Sibutramine hydrochloric (Ql-Sibutramine)、Fertility、Early Embryonic Development
13
R73(肿瘤学)
2004-03-26（万方平台首次上网日期，不代表论文的发表时间）
共1页
240
